Mark Sculpher is Professor of Health Economics at the Centre for Health Economics, University of York, UK where he is Director of the Programme on Economic Evaluation and Health Technology Assessment. He is also Deputy Director of the Policy Research Unit in Economic Evaluation of Health and Care Interventions, run collaboratively with the University of Sheffield and funded by the UK Department of Health. He has researched in a range of clinical areas including heart disease, cancer, diagnostics and public health. He has also contributed to methods in the field, in particular relating to decision analytic modelling and techniques to handle uncertainty, heterogeneity and generalisability. He is a co-author of two major text books in the area: Methods for the Economic Evaluation of Health Care Programmes (OUP, 2005) and Decision Modelling for Health Economic Evaluation (OUP, 2006). Mark is a member of the UK National Institute of Health Research (NIHR) College of Senior Investigators. He currently sits on NICE’s Diagnostics Advisory Committee. He chaired NICE’s 2004 Task Group on methods guidance for economic evaluation and advised the Methods Working Party for the 2008 update of this guidance; he has also advised health systems internationally on HTA methods including those in France, Ireland, Germany, Portugal and New Zealand. He is currently a member of the UK Department of Health’s Policy Research Programme’s Commissioning Panel.